Rodatristat ethyl

Name: Rodatristat ethyl
Brand: TargetMol
SKU: T16779
Price: 60 USD
Availability: InStock
Rating: 4.5 (1 reviews)

Catalog No. T16779Cas No. 1673571-51-1

Alias RVT-1201, RVT-014, KAR5585

Rodatristat ethyl (KAR5585) is a groundbreaking, orally active, and potent inhibitor of tryptophan hydroxylase 1 (TPH1) that significantly reduces 5-hydroxytryptamine (5-HT) levels and decreases pulmonary arterial hypertension (PAH) at low concentrations.

Rodatristat ethyl

Catalog No. T16779Alias RVT-1201, RVT-014, KAR5585Cas No. 1673571-51-1

Pack Size	Price	Availability
25 mg	$2,390	10-14 weeks
50 mg	$3,870	10-14 weeks
100 mg	$6,230	10-14 weeks

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Product Introduction

Bioactivity

Description	Rodatristat ethyl (KAR5585) is a groundbreaking, orally active, and potent inhibitor of tryptophan hydroxylase 1 (TPH1) that significantly reduces 5-hydroxytryptamine (5-HT) levels and decreases pulmonary arterial hypertension (PAH) at low concentrations.
In vivo	In male Sprague-Dawley rats, oral administration of rodatristat ethyl at doses of 100 or 200 mg/kg once daily for 28 days results in a dose-dependent decrease in serum, gut, and lung 5-HT levels. This treatment significantly reduces pulmonary arterial pressure as well as pulmonary vessel wall thickness and occlusion in rats with monocrotaline (MCT)-induced pulmonary hypertension[2].
Alias	RVT-1201, RVT-014, KAR5585

Chemical Properties

Molecular Weight	590.04
Formula	C₂₉H₃₁ClF₃N₅O₃
Cas No.	1673571-51-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 90 mg/mL (152.53 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6948 mL	8.4740 mL	16.9480 mL	84.7400 mL
5 mM	0.3390 mL	1.6948 mL	3.3896 mL	16.9480 mL
10 mM	0.1695 mL	0.8474 mL	1.6948 mL	8.4740 mL
20 mM	0.0847 mL	0.4237 mL	0.8474 mL	4.2370 mL
50 mM	0.0339 mL	0.1695 mL	0.3390 mL	1.6948 mL
100 mM	0.0169 mL	0.0847 mL	0.1695 mL	0.8474 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc